ATP13A4

Across TCGA cell cohorts, ATP13A4 mutation is significantly associated with the RNA expression of many other genes, with 439 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATP13A4-associated genes across cancer lineages are GRIFIN, DEFB124, and OR10A5. Each is linked with ATP13A4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP13A4-to-partner and partner-to-ATP13A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GRIFIN grouped by ATP13A4-low versus ATP13A4-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP13A4→partner) and Y-score (partner→ATP13A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GRIFIN →	+0.080	+4.906	<.001	.006	3	2
LUNG_NSCLC_LUSC	DEFB124 →	+0.187	+4.108	<.001	.005	3	1
OESOPHAGUS	OR10A5 →	+0.030	+4.906	<.001	.006	3	1
BLOOD_Leukemia	NKX2-6 →	+0.591	+5.201	<.001	.006	3	1
BLOOD_Leukemia	TLE7 →	+0.042	+5.969	<.001	.001	3	1
LUNG_NSCLC_LUAD	NANOG →	+0.033	+3.766	.008	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 439 associations by consensus.

GRIFIN by ATP13A4 expression — OESOPHAGUS

Explore this box plot interactively →