ATP13A3

Across TCGA pan-cancer cohorts, ATP13A3 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ATP13A3 data layer compared with 21 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ATP13A3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ATP13A3 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

COAD, READ, and KICH are the cancer types where ATP13A3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.319	0.810	<.001	35	view →
READ	OS	Median	II,III,IV	0.111	0.919	<.001	33	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
SKCM	DFS	Median	All	0.811	0.609	.021	7	view →
SARC	DFS	Median	All	0.095	0.632	.002	6	view →
STAD	OS	Median	III,IV	0.184	0.641	.011	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ATP13A3–COAD (OS)

Open the COAD breakdown →