ATP13A3

Across TCGA patient cohorts, ATP13A3 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP13A3-associated genes across cancer lineages are GAPDH, FOXO3a, and Bap1-c-4. Each is linked with ATP13A3 in more than 3 cancer types. Because this analysis shows association rather than direction, both ATP13A3-to-partner and partner-to-ATP13A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by ATP13A3-low versus ATP13A3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP13A3→partner) and Y-score (partner→ATP13A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GAPDH →	+0.643	+3.008	.014	.019	3	4
SKCM	FOXO3a →	-0.105	-2.584	.048	.011	3	2
SKCM	Bap1-c-4 →	+0.349	+3.321	.012	.009	3	2
UCEC	Caspase-8 →	-0.246	-1.999	.001	<.001	3	2
SKCM	C-Raf_pS338 →	-0.160	-3.169	.006	.017	3	2
UCEC	MEK1 →	+0.351	+2.807	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

GAPDH by ATP13A3 expression — COAD

Explore this box plot interactively →