ATP13A2

Across TCGA patient cohorts, ATP13A2 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP13A2-associated genes across cancer lineages are ATM, 4E-BP1_pT70, and Notch1. Each is linked with ATP13A2 in more than 3 cancer types. Because this analysis shows association rather than direction, both ATP13A2-to-partner and partner-to-ATP13A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ATP13A2-low versus ATP13A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP13A2→partner) and Y-score (partner→ATP13A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.471	-2.794	.002	.002	3	4
COAD	4E-BP1_pT70 →	+0.170	+2.815	.009	.036	3	3
UCEC	Notch1 →	+0.194	+2.424	<.001	.001	3	3
STAD	mTOR_pS2448 →	-0.275	-3.169	<.001	.019	1	4
STAD	c-Jun_pS73 →	-0.214	-3.000	.018	.034	3	2
UCEC	Cyclin-B1 →	+0.637	+3.906	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

ATM by ATP13A2 expression — UCEC

Explore this box plot interactively →