ATP13A2

Across TCGA cell cohorts, ATP13A2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,392 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ATP13A2-associated GO terms across cancer lineages are Negative regulation of protein catabolic process in the vacuole, Negative regulation of lysosomal protein catabolic process, and Extracellular exosome biogenesis. Each is linked with ATP13A2 in more than 18 cancer types. Because this analysis shows association rather than direction, both ATP13A2-to-partner and partner-to-ATP13A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of protein catabolic process in the vacuole grouped by ATP13A2-low versus ATP13A2-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP13A2→partner) and Y-score (partner→ATP13A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Negative regulation of protein catabolic process in the vacuole →	+0.191	+1.179	<.001	<.001	3	19
OVARY	Negative regulation of lysosomal protein catabolic process →	+0.191	+1.179	<.001	<.001	3	19
LUNG_NSCLC_LUSC	Extracellular exosome biogenesis →	+0.196	+1.131	<.001	<.001	3	18
LIVER	Extracellular vesicle biogenesis →	+0.165	+0.754	.001	.002	2	16
OVARY	Positive regulation of exosomal secretion →	+0.136	+1.095	<.001	<.001	3	14
BLOOD_Myeloma	Regulation of autophagosome size →	+0.119	+1.991	.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,392 associations by consensus.

Negative regulation of protein catabolic process in the vacuole by ATP13A2 expression — OVARY

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