ATP13A2

Across TCGA cell cohorts, ATP13A2 mutation is significantly associated with the RNA expression of many other genes, with 106 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATP13A2-associated genes across cancer lineages are DEFB132, PARD6A, and GALR3. Each is linked with ATP13A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP13A2-to-partner and partner-to-ATP13A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB132 grouped by ATP13A2-low versus ATP13A2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP13A2→partner) and Y-score (partner→ATP13A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DEFB132 →	+0.019	+5.029	<.001	.006	3	2
LARGE_INTESTINE	PARD6A →	+0.834	+3.588	.001	<.001	3	2
LARGE_INTESTINE	GALR3 →	+0.070	+3.839	.008	<.001	3	2
LARGE_INTESTINE	ZNF232 →	+0.896	+3.087	<.001	.006	3	2
OVARY	IL1F10 →	+0.158	+2.974	<.001	.006	3	1
OVARY	BPIFC →	+0.130	+3.070	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 106 associations by consensus.

DEFB132 by ATP13A2 expression — LUNG_SCLC

Explore this box plot interactively →