ATP13A1

Across TCGA patient cohorts, ATP13A1 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP13A1-associated genes across cancer lineages are Caspase-7-cleavedD198, VEGFR2, and PCNA. Each is linked with ATP13A1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ATP13A1-to-partner and partner-to-ATP13A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ATP13A1-low versus ATP13A1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP13A1→partner) and Y-score (partner→ATP13A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.654	+2.330	<.001	.020	3	4
STAD	VEGFR2 →	+0.330	+3.021	.036	.018	3	2
COAD	PCNA →	+0.243	+2.330	.030	.020	2	3
COAD	Cyclin-E1 →	+0.449	+3.169	<.001	.017	3	2
UCEC	Ku80 →	+0.200	+1.331	.005	.017	3	2
UCEC	Notch1 →	+0.185	+2.335	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Caspase-7-cleavedD198 by ATP13A1 expression — COAD

Explore this box plot interactively →