ATP12A

Across TCGA pan-cancer cohorts, ATP12A mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ATP12A data layer compared with 23 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ATP12A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ATP12A expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

HNSC, PDAC, and LSCC are the cancer types where ATP12A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.434	0.952	.004	24	view →
PDAC	OS	Median	All	0.923	0.718	.015	3	view →
LSCC	DFS	Median	All	1.000	0.328	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ATP12A–HNSC (DFS)

Open the HNSC breakdown →