ATP11C

Across TCGA patient cohorts, ATP11C mutation is significantly associated with the RNA expression of many other genes, with 5,522 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP11C-associated genes across cancer lineages are SAAL1, RFC2, and TIPIN. Each is linked with ATP11C in more than 3 cancer types. Because this analysis shows association rather than direction, both ATP11C-to-partner and partner-to-ATP11C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SAAL1 grouped by ATP11C-low versus ATP11C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP11C→partner) and Y-score (partner→ATP11C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SAAL1 →	+0.374	+1.343	<.001	<.001	3	4
STAD	RFC2 →	+0.615	+3.203	.004	.009	3	4
STAD	TIPIN →	+0.592	+3.182	.001	.009	3	4
UCEC	SNW1 →	+0.267	+1.343	.007	<.001	3	4
UCEC	AUNIP →	+0.522	+1.436	<.001	<.001	3	4
UCEC	EMC8 →	+0.452	+2.448	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,522 associations by consensus.

SAAL1 by ATP11C expression — UCEC

Explore this box plot interactively →