ATP11C

Across TCGA patient cohorts, ATP11C mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP11C-associated genes across cancer lineages are ATM, GSK3-a-b, and 14-3-3_beta. Each is linked with ATP11C in more than 2 cancer types. Because this analysis shows association rather than direction, both ATP11C-to-partner and partner-to-ATP11C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ATP11C-low versus ATP11C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP11C→partner) and Y-score (partner→ATP11C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.406	-1.638	<.001	.004	3	3
LUSC	GSK3-a-b →	+0.229	+2.834	.007	.034	3	2
UCEC	14-3-3_beta →	-0.092	-2.496	<.001	<.001	3	2
COAD	eEF2 →	+0.483	+2.815	.002	.036	3	2
UCEC	EGFR_pY1068 →	-0.223	-1.584	<.001	.002	3	2
UCEC	ERK2 →	+0.145	+1.222	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

ATM by ATP11C expression — UCEC

Explore this box plot interactively →