ATP11C

Across TCGA cell cohorts, ATP11C mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATP11C-associated genes across cancer lineages are HIGD1C, FCN2, and CD300LD. Each is linked with ATP11C in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP11C-to-partner and partner-to-ATP11C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HIGD1C grouped by ATP11C-low versus ATP11C-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP11C→partner) and Y-score (partner→ATP11C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HIGD1C →	+0.054	+3.786	<.001	.002	3	2
BLOOD_Lymphoma	FCN2 →	+0.048	+4.714	<.001	.002	3	2
OESOPHAGUS	CD300LD →	+0.013	+4.906	<.001	.006	3	1
BLOOD_Leukemia	KCNA5 →	+1.183	+3.681	<.001	.003	3	1
BLOOD_Leukemia	C16orf92 →	+0.123	+3.359	<.001	.002	3	1
BLOOD_Leukemia	ADIG →	+0.012	+4.247	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

HIGD1C by ATP11C expression — BLOOD_Leukemia

Explore this box plot interactively →