Across TCGA pan-cancer cohorts, ATP10A RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ATP10A data layer compared with 9 for mutation status.
The strongest signal is observed in uveal melanoma (UVM), where higher ATP10A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ATP10A expression acts as an unfavorable survival marker, although some lineages such as HNSC and CHOL show a favorable association.
UVM, ACC, and LUSC are the cancer types where ATP10A RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.