ATOH1

Across TCGA patient cohorts, ATOH1 mutation is significantly associated with the RNA expression of many other genes, with 853 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATOH1-associated genes across cancer lineages are SNX18P10, LCEP1, and RN7SL429P. Each is linked with ATOH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATOH1-to-partner and partner-to-ATOH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNX18P10 grouped by ATOH1-low versus ATOH1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATOH1→partner) and Y-score (partner→ATOH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SNX18P10 →	+0.060	+3.402	<.001	.007	3	2
PRAD	LCEP1 →	+0.329	+7.939	<.001	.008	3	2
CESC	RN7SL429P →	+0.182	+6.569	<.001	.001	3	2
LUAD	RNU6-4P →	+0.607	+3.344	.001	.001	3	2
LUAD	TYMSP2 →	+0.068	+3.343	<.001	.006	3	2
SKCM	CHMP4AP1 →	+0.036	+4.897	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 853 associations by consensus.

SNX18P10 by ATOH1 expression — SKCM

Explore this box plot interactively →