ATOH1

Across TCGA patient cohorts, ATOH1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATOH1-associated genes across cancer lineages are AR, Cyclin-E2, and EGFR_pY1068. Each is linked with ATOH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATOH1-to-partner and partner-to-ATOH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AR grouped by ATOH1-low versus ATOH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATOH1→partner) and Y-score (partner→ATOH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AR →	-0.546	-3.584	.002	.002	3	2
UCEC	Cyclin-E2 →	+0.187	+2.179	.021	.034	3	2
UCEC	EGFR_pY1068 →	-0.249	-2.321	.040	.034	3	1
UCEC	FASN →	+0.469	+2.459	.013	.020	3	1
UCEC	Ku80 →	+0.283	+2.472	.013	.011	3	1
UCEC	Myosin-IIa_pS1943 →	+0.229	+3.169	.021	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

AR by ATOH1 expression — UCEC

Explore this box plot interactively →