ATOH1

Across TCGA cell cohorts, ATOH1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,204 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATOH1-associated GO terms across cancer lineages are G protein-coupled acetylcholine receptor signaling pathway, Positive regulation of telomere maintenance via telomere lengthening, and Regulation of RNA stability. Each is linked with ATOH1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ATOH1-to-partner and partner-to-ATOH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, G protein-coupled acetylcholine receptor signaling pathway grouped by ATOH1-low versus ATOH1-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ATOH1→partner) and Y-score (partner→ATOH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	G protein-coupled acetylcholine receptor signaling pathway →	-0.135	-0.031	<.001	.001	3	4
BONE	Positive regulation of telomere maintenance via telomere lengthening →	+0.064	+0.046	.001	.005	3	4
SOFT_TISSUE	Regulation of RNA stability →	+0.049	+0.034	<.001	.003	2	5
UPPER_AERODIGESTIVE_TRACT	Regulation of transferase activity →	+0.044	+0.035	<.001	.009	3	4
BONE	Spindle organization →	+0.086	+0.060	<.001	.009	3	4
LARGE_INTESTINE	Mesodermal cell differentiation →	-0.113	-0.950	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,204 associations by consensus.

G protein-coupled acetylcholine receptor signaling pathway by ATOH1 expression — SOFT_TISSUE

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