ATL2

Across TCGA patient cohorts, ATL2 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATL2-associated genes across cancer lineages are A-Raf_pS299, Ku80, and Notch1. Each is linked with ATL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATL2-to-partner and partner-to-ATL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by ATL2-low versus ATL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATL2→partner) and Y-score (partner→ATL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.157	-2.000	.003	.032	3	2
UCEC	Ku80 →	+0.266	+2.179	.012	.034	3	2
UCEC	Notch1 →	+0.141	+3.009	.026	.019	3	2
UCEC	EGFR_pY1068 →	-0.305	-3.807	.007	<.001	3	1
UCEC	ERK2 →	+0.261	+2.459	.002	.019	3	1
UCEC	MEK1 →	+0.345	+3.459	.036	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

A-Raf_pS299 by ATL2 expression — UCEC

Explore this box plot interactively →