ATIC

Across TCGA patient cohorts, ATIC mutation is significantly associated with the RNA expression of many other genes, with 893 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATIC-associated genes across cancer lineages are RN7SL134P, SALRNA3, and ELOCP24. Each is linked with ATIC in more than 2 cancer types. Because this analysis shows association rather than direction, both ATIC-to-partner and partner-to-ATIC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL134P grouped by ATIC-low versus ATIC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATIC→partner) and Y-score (partner→ATIC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL134P →	+0.099	+1.862	.001	.009	3	3
HNSC	SALRNA3 →	+0.053	+4.226	.007	.001	3	2
BLCA	ELOCP24 →	+0.558	+3.692	.002	.007	3	2
BLCA	KATNBL1P4 →	+0.062	+4.603	<.001	<.001	3	2
UCEC	TBRG1 →	+0.269	+1.939	.007	.009	3	2
COAD	MRM3 →	+0.630	+3.200	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 893 associations by consensus.

RN7SL134P by ATIC expression — UCEC

Explore this box plot interactively →