ATIC

Across TCGA patient cohorts, ATIC mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATIC-associated genes across cancer lineages are MEK1, mTOR_pS2448, and Notch1. Each is linked with ATIC in more than 1 cancer types. Because this analysis shows association rather than direction, both ATIC-to-partner and partner-to-ATIC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ATIC-low versus ATIC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATIC→partner) and Y-score (partner→ATIC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.308	+2.000	.019	.030	3	2
UCEC	mTOR_pS2448 →	-0.165	-3.687	.002	.001	3	2
UCEC	Notch1 →	+0.132	+1.713	.009	.024	3	2
UCEC	PCNA →	+0.287	+2.807	<.001	<.001	3	2
UCEC	PDCD4 →	-0.453	-2.321	.007	.033	3	2
UCEC	Annexin-1 →	+0.593	+2.926	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

MEK1 by ATIC expression — UCEC

Explore this box plot interactively →