ATIC

Across TCGA cell cohorts, ATIC RNA expression is significantly associated with the go_rna of many other GO terms, with 4,213 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ATIC-associated GO terms across cancer lineages are Nucleolar large rRNA transcription by RNA polymerase I, Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and rRNA processing. Each is linked with ATIC in more than 13 cancer types. Because this analysis shows association rather than direction, both ATIC-to-partner and partner-to-ATIC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleolar large rRNA transcription by RNA polymerase I grouped by ATIC-low versus ATIC-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ATIC→partner) and Y-score (partner→ATIC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Nucleolar large rRNA transcription by RNA polymerase I →	+0.114	+0.779	.001	.001	3	14
BLOOD_Lymphoma	Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.081	+0.703	<.001	<.001	3	13
BONE	rRNA processing →	+0.126	+0.827	.001	.003	3	12
LUNG_SCLC	tRNA metabolic process →	+0.061	+0.595	.001	.004	3	12
LIVER	Negative regulation of cell adhesion →	-0.113	-0.898	<.001	<.001	3	12
BLOOD_Lymphoma	rRNA metabolic process →	+0.089	+0.638	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,213 associations by consensus.

Nucleolar large rRNA transcription by RNA polymerase I by ATIC expression — BONE

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