ATIC

Across TCGA cell cohorts, ATIC mutation is significantly associated with the drug of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATIC-associated genes across cancer lineages are Sabutoclax, KRAS (G12C) Inhibitor-12, and GSK690693. Each is linked with ATIC in more than 1 cancer types. Because this analysis shows association rather than direction, both ATIC-to-partner and partner-to-ATIC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sabutoclax grouped by ATIC-low versus ATIC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATIC→partner) and Y-score (partner→ATIC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Sabutoclax →	+0.473	+2.769	.025	.040	3	1
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.646	+2.646	.008	.047	3	1
LARGE_INTESTINE	GSK690693 →	+0.681	+2.710	.006	.027	3	1
LARGE_INTESTINE	Leflunomide →	+0.303	+2.769	.017	.040	2	1
LARGE_INTESTINE	IC-87114 →	+0.213	+2.652	.039	.045	2	1
LARGE_INTESTINE	QL-XII-61 →	+0.491	+2.672	.004	.039	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Sabutoclax by ATIC expression — LARGE_INTESTINE

Explore this box plot interactively →