Across TCGA pan-cancer cohorts, ATG7 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated ATG7 data layer compared with 25 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher ATG7 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ATG7 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

SKCM and UCEC are the cancer types where ATG7 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	III,IV	0.323	0.709	.009	10	view →
UCEC	DFS	Median	II,III,IV	0.915	0.305	.018	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: ATG7 tumor-vs-normal RNA expression · all ATG7 data types