ATG4D

mass-spec protein — tumor vs normal
Tumor vs Normalmass-specBox plot · TCGA cohorts

Across TCGA pan-cancer cohorts, ATG4D mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of ATG4D’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where ATG4D mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ATG4D is over-expressed in tumor.

LSCC and HNSC are the cancer types where ATG4D tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATG4D mass-spec protein (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.
LineageGenderStageFold-changepSampling consensus
LSCCMaleII,III,IV+0.493<.0017view →
HNSCAllAll+0.524.0396view →
Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

ATG4D–LSCC

Tumor-vs-normal mass-spec protein box plot for ATG4D in LSCC.

Open the LSCC breakdown →

Exploration