ATG4B

Across TCGA pan-cancer cohorts, ATG4B mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ATG4B’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where ATG4B mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ATG4B is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

LSCC, CCRCC, and OV are the cancer types where ATG4B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATG4B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	All	III,IV	+0.268	<.001	8	view →
CCRCC	Male	All	−0.187	<.001	6	view →
OV	All	All	+0.284	.018	2	view →
PDAC	Female	All	+0.166	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

ATG4B–LSCC

Open the LSCC breakdown →