ATG4A

Across TCGA pan-cancer cohorts, ATG4A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ATG4A data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ATG4A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ATG4A expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, OV, and LSCC are the cancer types where ATG4A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.932	0.776	.001	30	view →
OV	DFS	Tertile	All	0.683	1.000	.045	8	view →
LSCC	OS	Median	III,IV	0.545	0.902	.018	8	view →
CCRCC	OS	Tertile	All	1.000	0.851	.032	7	view →
UCEC	DFS	Median	II,III,IV	0.911	0.597	.046	4	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ATG4A–HNSC (OS)

Open the HNSC breakdown →