ATG4A

Across TCGA patient cohorts, ATG4A mutation is significantly associated with the RNA expression of many other genes, with 1,946 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATG4A-associated genes across cancer lineages are LINC01723, RN7SL546P, and RCC2P5. Each is linked with ATG4A in more than 1 cancer types. Because this analysis shows association rather than direction, both ATG4A-to-partner and partner-to-ATG4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01723 grouped by ATG4A-low versus ATG4A-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG4A→partner) and Y-score (partner→ATG4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LINC01723 →	+0.038	+4.246	<.001	<.001	3	2
SKCM	RN7SL546P →	+0.197	+2.847	<.001	.002	3	2
SKCM	RCC2P5 →	+0.052	+2.743	<.001	.008	3	2
UCEC	FBXO7 →	+0.413	+2.413	<.001	<.001	3	2
LUAD	C1orf68 →	+0.234	+5.888	<.001	.002	3	2
LUAD	COX6CP11 →	+0.250	+6.315	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,946 associations by consensus.

LINC01723 by ATG4A expression — SKCM

Explore this box plot interactively →