ATG4A

Across TCGA patient cohorts, ATG4A mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATG4A-associated genes across cancer lineages are p38-MAPK_pT180_Y182, Tuberin, and EGFR_pY1068. Each is linked with ATG4A in more than 1 cancer types. Because this analysis shows association rather than direction, both ATG4A-to-partner and partner-to-ATG4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by ATG4A-low versus ATG4A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG4A→partner) and Y-score (partner→ATG4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.511	-1.986	.003	.010	3	2
UCEC	Tuberin →	+0.416	+2.232	<.001	.005	3	2
UCEC	EGFR_pY1068 →	-0.272	-2.502	.005	.002	3	1
UCEC	A-Raf_pS299 →	-0.103	-2.321	.028	.034	3	1
UCEC	FoxM1 →	+0.217	+2.000	.033	.010	3	1
UCEC	JNK2 →	+0.251	+3.196	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

p38-MAPK_pT180_Y182 by ATG4A expression — UCEC

Explore this box plot interactively →