ATG4A

Across TCGA cell cohorts, ATG4A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,489 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ATG4A-associated GO terms across cancer lineages are Protein delipidation, Aggrephagy, and Nucleophagy. Each is linked with ATG4A in more than 18 cancer types. Because this analysis shows association rather than direction, both ATG4A-to-partner and partner-to-ATG4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein delipidation grouped by ATG4A-low versus ATG4A-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG4A→partner) and Y-score (partner→ATG4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Protein delipidation →	+0.126	+0.997	<.001	<.001	3	19
LUNG_SCLC	Aggrephagy →	+0.100	+0.838	.002	.004	3	16
CNS	Nucleophagy →	+0.087	+0.919	<.001	<.001	3	11
BLOOD_Lymphoma	Golgi vesicle transport →	+0.060	+0.738	<.001	<.001	3	11
LIVER	Regulation of cytoplasmic translational elongation →	-0.180	-1.093	.002	<.001	3	11
BLOOD_Myeloma	Microautophagy →	+0.078	+0.924	.001	.003	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,489 associations by consensus.

Protein delipidation by ATG4A expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →