ATG4A

Across TCGA cell cohorts, ATG4A mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATG4A-associated genes across cancer lineages are MT1B, S100A7A, and ZNF705G. Each is linked with ATG4A in more than 1 cancer types. Because this analysis shows association rather than direction, both ATG4A-to-partner and partner-to-ATG4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MT1B grouped by ATG4A-low versus ATG4A-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG4A→partner) and Y-score (partner→ATG4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MT1B →	+1.207	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	S100A7A →	+0.035	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	ZNF705G →	+0.006	+4.867	<.001	.009	3	1
LARGE_INTESTINE	AMELY →	+0.030	+4.022	<.001	.006	3	1
LARGE_INTESTINE	PRH2 →	+0.179	+3.415	<.001	.009	2	1
LARGE_INTESTINE	NAA11 →	+0.409	+3.443	<.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MT1B by ATG4A expression — BLOOD_Lymphoma

Explore this box plot interactively →