ATG3

Across TCGA patient cohorts, ATG3 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATG3-associated genes across cancer lineages are MEK1, Notch1, and STAT3_pY705. Each is linked with ATG3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATG3-to-partner and partner-to-ATG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ATG3-low versus ATG3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG3→partner) and Y-score (partner→ATG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.525	+3.807	.001	<.001	3	1
UCEC	Notch1 →	+0.212	+2.700	<.001	.006	3	1
UCEC	STAT3_pY705 →	-0.458	-2.000	<.001	.032	3	1
UCEC	Syk →	+0.348	+3.000	.039	.036	3	1
UCEC	Tuberin →	+0.329	+2.000	.006	.032	3	1
UCEC	ASNS →	+0.503	+3.169	.002	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MEK1 by ATG3 expression — UCEC

Explore this box plot interactively →