ATG3

Across TCGA cell cohorts, ATG3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,613 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ATG3-associated GO terms across cancer lineages are Regulation of DNA damage checkpoint, Regulation of chromosome segregation, and Regulation of mitotic sister chromatid separation. Each is linked with ATG3 in more than 9 cancer types. Because this analysis shows association rather than direction, both ATG3-to-partner and partner-to-ATG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA damage checkpoint grouped by ATG3-low versus ATG3-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG3→partner) and Y-score (partner→ATG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA damage checkpoint →	+0.107	+0.778	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Regulation of chromosome segregation →	+0.137	+0.684	<.001	.002	3	10
UPPER_AERODIGESTIVE_TRACT	Regulation of mitotic sister chromatid separation →	+0.161	+0.800	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Regulation of metaphase/anaphase transition of cell cycle →	+0.134	+0.820	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Regulation of chromosome separation →	+0.166	+0.713	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Regulation of mitotic metaphase/anaphase transition →	+0.136	+0.815	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,613 associations by consensus.

Regulation of DNA damage checkpoint by ATG3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →