ATG16L2

Across TCGA patient cohorts, ATG16L2 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATG16L2-associated genes across cancer lineages are 4E-BP1, EGFR_pY1068, and eIF4E. Each is linked with ATG16L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATG16L2-to-partner and partner-to-ATG16L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by ATG16L2-low versus ATG16L2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG16L2→partner) and Y-score (partner→ATG16L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.338	+3.321	.001	.009	3	2
UCEC	EGFR_pY1068 →	-0.283	-3.169	.004	<.001	3	1
UCEC	eIF4E →	+0.222	+3.472	.007	.002	3	1
UCEC	A-Raf_pS299 →	-0.111	-3.321	.018	.010	3	1
UCEC	FoxM1 →	+0.240	+2.000	.018	.010	3	1
UCEC	ACC_pS79 →	+0.305	+1.884	.025	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

4E-BP1 by ATG16L2 expression — UCEC

Explore this box plot interactively →