ATG16L1

Across TCGA patient cohorts, ATG16L1 protein abundance is significantly associated with the RNA expression of many other genes, with 18,387 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ATG16L1-associated genes across cancer lineages are ATG5, LRRFIP1, and HEBP2. Each is linked with ATG16L1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ATG16L1-to-partner and partner-to-ATG16L1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ATG16L1 versus ATG5 in BRCA, with a Pearson correlation of 0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG16L1→partner) and Y-score (partner→ATG16L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ATG5 →	+0.551	+0.250	<.001	.001	3	5
BRCA	LRRFIP1 →	+0.587	+0.254	<.001	<.001	3	4
LUAD	HEBP2 →	+0.434	+0.194	.001	.001	3	4
UCEC	KAT2A →	-0.677	-0.255	.001	<.001	3	4
HNSC	CLCN2 →	-0.504	-0.186	.003	<.001	3	4
UCEC	CENPF →	-1.143	-0.256	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,387 associations by consensus.

ATG16L1 vs ATG5 — BRCA

Explore this scatter interactively →