ATG16L1

Across TCGA patient cohorts, ATG16L1 mutation is significantly associated with the RNA expression of many other genes, with 2,220 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATG16L1-associated genes across cancer lineages are MIR615, H3P5, and SNORD90. Each is linked with ATG16L1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ATG16L1-to-partner and partner-to-ATG16L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR615 grouped by ATG16L1-low versus ATG16L1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG16L1→partner) and Y-score (partner→ATG16L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR615 →	+0.690	+3.413	<.001	.006	3	3
HNSC	H3P5 →	+0.220	+4.840	<.001	<.001	3	2
BRCA	SNORD90 →	+0.198	+3.332	.004	.009	3	2
HNSC	MIR545 →	+0.285	+5.178	<.001	.002	3	2
UCEC	XPNPEP1 →	+0.334	+2.010	.002	.001	3	2
UCEC	COMMD9 →	+0.333	+1.698	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,220 associations by consensus.

MIR615 by ATG16L1 expression — CESC

Explore this box plot interactively →