ATG16L1

Across TCGA patient cohorts, ATG16L1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATG16L1-associated genes across cancer lineages are Notch1, VHL, and ASNS. Each is linked with ATG16L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATG16L1-to-partner and partner-to-ATG16L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by ATG16L1-low versus ATG16L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG16L1→partner) and Y-score (partner→ATG16L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.097	+1.598	.033	.040	3	2
UCEC	VHL →	-0.804	-1.662	<.001	.010	3	2
UCEC	ASNS →	+0.266	+1.362	.023	.034	3	2
UCEC	ATM →	-0.455	-2.308	.001	.005	3	2
UCEC	Cyclin-B1 →	+0.500	+1.459	.006	.012	3	2
UCEC	14-3-3_beta →	-0.092	-2.880	.004	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Notch1 by ATG16L1 expression — UCEC

Explore this box plot interactively →