ATG16L1

Across TCGA cell cohorts, ATG16L1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,374 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ATG16L1-associated GO terms across cancer lineages are Protein localization to phagophore assembly site, C-terminal protein lipidation, and C-terminal protein amino acid modification. Each is linked with ATG16L1 in more than 13 cancer types. Because this analysis shows association rather than direction, both ATG16L1-to-partner and partner-to-ATG16L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to phagophore assembly site grouped by ATG16L1-low versus ATG16L1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG16L1→partner) and Y-score (partner→ATG16L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Protein localization to phagophore assembly site →	+0.121	+0.981	<.001	<.001	3	14
URINARY_TRACT	C-terminal protein lipidation →	+0.195	+0.676	<.001	.003	3	13
URINARY_TRACT	C-terminal protein amino acid modification →	+0.191	+0.922	<.001	.002	3	12
UPPER_AERODIGESTIVE_TRACT	Protein depolymerization →	+0.119	+0.850	<.001	.001	3	12
BONE	Chromosome separation →	+0.192	+1.221	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Phosphatidylinositol biosynthetic process →	+0.069	+0.875	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,374 associations by consensus.

Protein localization to phagophore assembly site by ATG16L1 expression — BREAST

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