ATG16L1

Across TCGA cell cohorts, ATG16L1 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATG16L1-associated genes across cancer lineages are KRTAP2-2, PPA2, and ZNF490. Each is linked with ATG16L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATG16L1-to-partner and partner-to-ATG16L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP2-2 grouped by ATG16L1-low versus ATG16L1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG16L1→partner) and Y-score (partner→ATG16L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KRTAP2-2 →	+0.083	+4.817	<.001	.001	3	1
LARGE_INTESTINE	PPA2 →	+0.740	+3.064	<.001	.009	3	1
LARGE_INTESTINE	ZNF490 →	+0.474	+3.215	.004	.009	3	1
BLOOD_Leukemia	GOT1L1 →	+0.080	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	HTR3D →	+0.019	+5.539	<.001	.003	3	1
BLOOD_Leukemia	RBMY1D →	+0.180	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

KRTAP2-2 by ATG16L1 expression — LUNG_SCLC

Explore this box plot interactively →