ATG13

Across TCGA patient cohorts, ATG13 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATG13-associated genes across cancer lineages are ERK2, FOXO3a_pS318_S321, and Acetyl-a-Tubulin-Lys40. Each is linked with ATG13 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATG13-to-partner and partner-to-ATG13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by ATG13-low versus ATG13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG13→partner) and Y-score (partner→ATG13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.192	+2.459	.039	.020	3	2
UCEC	FOXO3a_pS318_S321 →	-0.121	-2.459	.045	.020	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.644	+3.009	.008	.019	3	1
UCEC	MEK1 →	+0.442	+3.169	.012	.019	3	1
UCEC	PCNA →	+0.311	+2.459	.002	.020	2	2
UCEC	Rab11 →	-0.182	-2.999	.009	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

ERK2 by ATG13 expression — UCEC

Explore this box plot interactively →