ATG12

Across TCGA patient cohorts, ATG12 protein abundance is significantly associated with the RNA expression of many other genes, with 6,879 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ATG12-associated genes across cancer lineages are SCML2, PCYT1B, and EIF3E. Each is linked with ATG12 in more than 2 cancer types. Because this analysis shows association rather than direction, both ATG12-to-partner and partner-to-ATG12 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ATG12 versus SCML2 in LSCC, with a Pearson correlation of -0.28.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG12→partner) and Y-score (partner→ATG12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SCML2 →	-1.001	-0.349	<.001	<.001	3	3
LSCC	PCYT1B →	-0.671	-0.275	<.001	<.001	3	3
BRCA	EIF3E →	-0.415	-0.233	.002	.006	3	3
HNSC	MORC2 →	-0.381	-0.217	.008	<.001	3	3
BRCA	NT5C3B →	-0.578	-0.313	.004	.003	3	3
HNSC	ZNF711 →	-1.141	-0.322	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,879 associations by consensus.

ATG12 vs SCML2 — LSCC

Explore this scatter interactively →