ATG12

Across TCGA patient cohorts, ATG12 mutation is significantly associated with the RNA expression of many other genes, with 43 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible ATG12-associated genes across cancer lineages are RN7SL627P, RNA5SP205, and KRT16P3. Each is linked with ATG12 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATG12-to-partner and partner-to-ATG12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL627P grouped by ATG12-low versus ATG12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATG12→partner) and Y-score (partner→ATG12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL627P →	+0.160	+5.027	<.001	.004	3	1
COAD	RNA5SP205 →	+0.431	+6.917	<.001	<.001	3	1
COAD	KRT16P3 →	+0.088	+5.435	<.001	.005	3	1
COAD	OR51K1P →	+0.320	+5.212	<.001	.007	3	1
COAD	PCMTD1P2 →	+0.140	+6.392	<.001	.001	3	1
COAD	RN7SL131P →	+0.182	+5.693	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

RN7SL627P by ATG12 expression — UCEC

Explore this box plot interactively →