ATF7

Across TCGA patient cohorts, ATF7 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATF7-associated genes across cancer lineages are Rad50, ASNS, and Caspase-7-cleavedD198. Each is linked with ATF7 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATF7-to-partner and partner-to-ATF7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by ATF7-low versus ATF7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATF7→partner) and Y-score (partner→ATF7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.211	-2.087	.023	.005	3	2
UCEC	ASNS →	+0.461	+2.700	<.001	.006	3	2
UCEC	Caspase-7-cleavedD198 →	+0.676	+3.720	.002	<.001	3	2
UCEC	EGFR_pY1068 →	-0.344	-3.807	<.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.123	-2.584	.007	.001	3	1
UCEC	ERK2 →	+0.192	+2.087	.009	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Rad50 by ATF7 expression — UCEC

Explore this box plot interactively →