ATF7

Across TCGA cell cohorts, ATF7 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,791 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible ATF7-associated GO terms across cancer lineages are Regulation of chromatin organization, Regulation of DNA damage checkpoint, and Cell proliferation in forebrain. Each is linked with ATF7 in more than 9 cancer types. Because this analysis shows association rather than direction, both ATF7-to-partner and partner-to-ATF7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of chromatin organization grouped by ATF7-low versus ATF7-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ATF7→partner) and Y-score (partner→ATF7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Regulation of chromatin organization →	+0.078	+0.824	<.001	.002	3	9
OVARY	Regulation of DNA damage checkpoint →	+0.086	+0.434	.001	.003	3	9
SOFT_TISSUE	Cell proliferation in forebrain →	+0.090	+0.737	.001	<.001	3	8
LIVER	Negative regulation of sister chromatid cohesion →	+0.106	+0.607	<.001	.001	3	8
LUNG_NSCLC_LUSC	Regulation of sister chromatid cohesion →	+0.146	+0.926	.001	<.001	3	8
OVARY	Error-prone translesion synthesis →	+0.070	+0.391	<.001	.001	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,791 associations by consensus.

Regulation of chromatin organization by ATF7 expression — BLOOD_Myeloma

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