ATF4

Across TCGA pan-cancer cohorts, ATF4 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ATF4 data layer compared with 29 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher ATF4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ATF4 expression acts as an unfavorable survival marker.

READ, CESC, and DLBC are the cancer types where ATF4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	All	0.173	0.828	<.001	39	view →
CESC	OS	Median	II,III,IV	0.068	0.830	<.001	24	view →
DLBC	OS	Median	All	0.053	0.936	<.001	12	view →
HNSC	OS	Median	All	0.166	0.710	.003	12	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ATF4–READ (OS)

Open the READ breakdown →