ATF4

Across TCGA patient cohorts, ATF4 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,163 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ATF4-associated proteins across cancer lineages are TNRC6B, EIF4ENIF1, and TTLL12. Each is linked with ATF4 in more than 4 cancer types. Because this analysis shows association rather than direction, both ATF4-to-partner and partner-to-ATF4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ATF4 versus TNRC6B in COAD, with a Pearson correlation of 0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ATF4→partner) and Y-score (partner→ATF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TNRC6B →	+0.284	+0.476	.002	<.001	3	5
BRCA	EIF4ENIF1 →	+0.267	+0.525	.001	<.001	3	5
LSCC	TTLL12 →	+0.397	+0.363	<.001	<.001	3	5
LSCC	NUP50 →	+0.208	+0.300	<.001	<.001	3	5
LSCC	DDX6 →	+0.159	+0.381	<.001	<.001	3	4
UCEC	MFN2 →	-0.218	-0.929	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,163 associations by consensus.

ATF4 vs TNRC6B — COAD

Explore this scatter interactively →