ATF4

Across TCGA patient cohorts, ATF4 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATF4-associated genes across cancer lineages are ACC_pS79, ACC1, and p62 Lck ligand. Each is linked with ATF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATF4-to-partner and partner-to-ATF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC_pS79 grouped by ATF4-low versus ATF4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATF4→partner) and Y-score (partner→ATF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC_pS79 →	+0.524	+2.817	.005	.036	3	1
UCEC	ACC1 →	+0.503	+3.169	.011	.020	3	1
UCEC	p62 Lck ligand →	+0.412	+3.169	.021	.020	3	1
UCEC	Tuberin_pT1462 →	+0.256	+2.817	.043	.036	3	1
UCEC	Cyclin-E2 →	+0.244	+2.817	.008	.036	3	1
UCEC	MEK1 →	+0.540	+3.169	.007	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

ACC_pS79 by ATF4 expression — UCEC

Explore this box plot interactively →