ATF4

Across TCGA cell cohorts, ATF4 RNA expression is significantly associated with the RNA expression of many other genes, with 5,553 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATF4-associated genes across cancer lineages are CHAC1, ADM2, and ASNS. Each is linked with ATF4 in more than 18 cancer types. Because this analysis shows association rather than direction, both ATF4-to-partner and partner-to-ATF4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ATF4 versus CHAC1 in BLOOD_Myeloma, with a Pearson correlation of 0.55.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATF4→partner) and Y-score (partner→ATF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CHAC1 →	+2.414	+0.796	.001	.004	2	19
BLOOD_Myeloma	ADM2 →	+2.603	+0.988	<.001	<.001	3	18
STOMACH	ASNS →	+2.320	+1.071	<.001	<.001	3	18
BLOOD_Myeloma	SESN2 →	+2.694	+1.104	<.001	<.001	3	17
KIDNEY	MTHFD2 →	+2.000	+0.646	.009	.007	1	19
OESOPHAGUS	MARS1 →	+1.482	+1.188	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,553 associations by consensus.

ATF4 vs CHAC1 — BLOOD_Myeloma

Explore this scatter interactively →