ATF4

Across TCGA cell cohorts, ATF4 protein abundance is significantly associated with the RNA expression of many other genes, with 3,196 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ATF4-associated genes across cancer lineages are FNDC3B, GANAB, and CD46. Each is linked with ATF4 in more than 5 cancer types. Because this analysis shows association rather than direction, both ATF4-to-partner and partner-to-ATF4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ATF4 versus FNDC3B in BLOOD_Leukemia, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATF4→partner) and Y-score (partner→ATF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FNDC3B →	+1.790	+1.096	.002	.003	3	6
BREAST	GANAB →	+0.919	+0.953	.003	.004	3	5
CNS	CD46 →	+0.623	+0.783	.006	.003	3	5
CNS	ATP6AP2 →	+0.770	+0.509	.001	.009	3	5
BONE	TADA1 →	-0.698	-1.060	.001	.001	2	6
LUNG_NSCLC_LUAD	IMPDH2 →	-0.499	-0.520	.004	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,196 associations by consensus.

ATF4 vs FNDC3B — BLOOD_Leukemia

Explore this scatter interactively →