ATF4

Across TCGA cell cohorts, ATF4 protein abundance is significantly associated with the go_rna of many other GO terms, with 1,721 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ATF4-associated GO terms across cancer lineages are Endothelial cell differentiation, Protein targeting to membrane, and Lung development. Each is linked with ATF4 in more than 4 cancer types. Because this analysis shows association rather than direction, both ATF4-to-partner and partner-to-ATF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endothelial cell differentiation grouped by ATF4-low versus ATF4-high in STOMACH.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ATF4→partner) and Y-score (partner→ATF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Endothelial cell differentiation →	+0.128	+0.570	.005	.001	3	5
LUNG_SCLC	Protein targeting to membrane →	+0.072	+0.762	.005	.009	3	5
BONE	Lung development →	+0.175	+1.060	<.001	.001	3	5
BONE	Regulation of isotype switching to IgG isotypes →	-0.143	-1.060	<.001	.001	3	5
LARGE_INTESTINE	Positive regulation of fibroblast growth factor receptor signaling pathway →	+0.140	+0.750	.002	<.001	3	4
STOMACH	Icosanoid transport →	-0.156	-0.689	.003	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,721 associations by consensus.

Endothelial cell differentiation by ATF4 expression — STOMACH

Explore this box plot interactively →