ATF4

Across TCGA cell cohorts, ATF4 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ATF4-associated genes across cancer lineages are NKX2-6, OR5P3, and FAM9A. Each is linked with ATF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATF4-to-partner and partner-to-ATF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NKX2-6 grouped by ATF4-low versus ATF4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATF4→partner) and Y-score (partner→ATF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NKX2-6 →	+0.663	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR5P3 →	+0.125	+5.201	<.001	.006	3	1
BLOOD_Leukemia	FAM9A →	+0.019	+5.539	<.001	.003	3	1
BLOOD_Leukemia	KRTAP21-2 →	+0.085	+5.539	<.001	.003	3	1
BLOOD_Leukemia	FAM24A →	+0.082	+5.969	<.001	.001	3	1
BLOOD_Leukemia	IZUMO3 →	+0.073	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

NKX2-6 by ATF4 expression — BLOOD_Leukemia

Explore this box plot interactively →