ATF2

Across TCGA patient cohorts, ATF2 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATF2-associated genes across cancer lineages are P-Cadherin, eIF4E, and JNK_pT183_Y185. Each is linked with ATF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ATF2-to-partner and partner-to-ATF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, P-Cadherin grouped by ATF2-low versus ATF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATF2→partner) and Y-score (partner→ATF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	P-Cadherin →	-0.137	-3.321	.011	.009	3	3
UCEC	eIF4E →	+0.161	+3.321	.041	.010	3	2
UCEC	JNK_pT183_Y185 →	-0.153	-2.584	.015	.010	3	2
UCEC	MEK1 →	+0.461	+4.000	<.001	<.001	3	2
UCEC	p27_pT157 →	-0.045	-1.768	.038	.026	3	2
UCEC	p70-S6K →	+0.147	+2.196	.041	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

P-Cadherin by ATF2 expression — UCEC

Explore this box plot interactively →