ATF2

Across TCGA cell cohorts, ATF2 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible ATF2-associated genes across cancer lineages are SSMEM1, MS4A14, and MMP26. Each is linked with ATF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATF2-to-partner and partner-to-ATF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SSMEM1 grouped by ATF2-low versus ATF2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATF2→partner) and Y-score (partner→ATF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SSMEM1 →	+0.030	+3.707	<.001	.009	3	1
LARGE_INTESTINE	MS4A14 →	+0.016	+4.054	<.001	.004	3	1
LARGE_INTESTINE	MMP26 →	+0.048	+4.217	<.001	.001	3	1
LARGE_INTESTINE	OR5V1 →	+0.008	+4.437	<.001	.004	3	1
BLOOD_Leukemia	LCE1C →	+0.432	+4.922	.002	.009	3	1
BLOOD_Leukemia	SLC5A8 →	+0.182	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

SSMEM1 by ATF2 expression — LARGE_INTESTINE

Explore this box plot interactively →